The Madikwe Game Reserve is not as busy as the Greater Kruger Game Reserves. It is the fifth-largest conservation area in the country and is home to the Big Five. It is also well known for the successful reintroduction and conservation of the endangered Painted Hunting Dogs also called Wild Dogs. They are extremely efficient hunters which used to prey upon farmers livestock and were nearly hunted to extinction.

Madikwe lies about 4.5 hours from Johannesburg along the border with neighbouring Botswana. There are several luxury lodges to choose from and the game viewing is excellent. As the park is less visited than the Sabi Sands and Kruger, guests get a more authentic and intimate safari experience.